Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Comparative Analgesic and Anti-inflammatory Activities of Two Polyherbal Tablet Formulations (Aujaie and Surangeen) in Rats

M S Akhtar¹, A Malik¹, M S Saleem¹, G Murtaza²

¹Faculty of Pharmacy, University of Sargodha, Sargodha; ²Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.

For correspondence:- G Murtaza Email: gmdogar356@gmail.com Tel:+923142082826

Received: 17 July 2012 Accepted: 26 June 2013 Published: 23 August 2013

Citation: Akhtar MS, Malik A, Saleem MS, Murtaza G. Comparative Analgesic and Anti-inflammatory Activities of Two Polyherbal Tablet Formulations (Aujaie and Surangeen) in Rats. Trop J Pharm Res 2013; 12(4):603-607 doi: 10.4314/tjpr.v12i4.24

© 2013 The authors.
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Abstract

Purpose: To investigate the analgesic and anti-inflammatory activities of two herbal polymedicines - Aujaie and Surangeen to ascertain their therapeutic claims.

Methods: A total of 96 rats were divided into two equal groups; one for determination of anti-inflammatory activity and the other for analgesic activity. Anti-inflammatory and analgesic activities were evaluated by carrageenan-induced paw edema and formalin-induced paw licking test, respectively. For both studies, group I (untreated control) received 1 ml/kg, (po) of gum suspension 1 h before carrageenan injection. Aspirin (100 mg/kg, po) was given to group II (treated control) before injection. Groups III, IV and V were administered orally aujaie (3, 4 and 5 mg/kg, po, respectively), while surangeen tablets (10, 20 and 40 mg/kg, po) were given to groups VI, VII and VIII, respectively. Pain was experimentally induced by injecting 0.1 ml of 2.5 % formalin (40 % formaldehyde in distilled water) via the subplantar region of the left hind paw.

Results: Significant (p < 0.05) anti-inflammatory activity for aspirin (group II as well as for groups III - VIII with paw edema inhibition (PDI) ranging from 24.6 - 90.2 %, There was significant ((p < 0.05) analgesic activity in group II, VI and VII while in groups III - V and VIII the activity was insignificant (p < 0.05).

Conclusion: Aujaie and surangeen tablets exhibited pronounced analgesic and anti-inflammatory activities in rats depending on the dose employed.

Keywords: Aujaie, Surangeen, Anti-inflammatory, Analgesic